Since its infancy in the 50’s, metathesis has grown in importance and, today, applications in a broad variety of areas such as natural product synthesis [7-11], polymerization , drug discovery , petrochemistry or agricultural chemistry have been reported.
One of the reasons of this success is the discovery of well-defined, stable, highly chemoselective and now commercially available catalysts particularly the Grubbs catalysts 1 A large array of functional groups including alcohols, halides, esters, amides, carbamates and sulfonamides are compatible with the metathesis conditions [14-20].
“Using chemistry we started out just by having fun, [but the result] is, now it is being used to make tank armor.” – Dr. Olefin metathesis is used to form polymers to create materials for bathroom sinks, stronger baseball bats, tank armor, Hepatitis C and Osteoporosis drugs, candles and for pest control.
In the orgotar world, mastering alkene metathesis means you are one of the strongest firebenders on the planet, because alkene metathesis is so useful.
Various approaches have been explored to allow the use of primary and secondary amines in ring-closing metathesis (RCM) and cross-metathesis (CM), and one of them is the transformation of amines into carbamates, amides or sulfonamides [27-29].